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September 28, 2010 | Tuesday 
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DOCS Clinic Opens at Overtown Shelter for Homeless Women

The Lotus House DOCS staff, from left, Michael Spertus, Rujuta Pandya, Elishia McKay and Janki Amin, and previous Lotus House project manager Prabhat Mishra celebrated the grand opening of the Lotus House Wellness Center last week.

After years of planning, the student-run organization that informally began bringing health care to underserved communities nearly 40 years ago celebrated the grand opening Thursday of a wellness clinic at the Lotus House, a sanctuary for homeless women and children in Overtown.

Beginning this Thursday, the Lotus House Wellness Center, the third community-based clinic in South Florida staffed by Miller School faculty and medical students through the Mitchell Wolfson Sr. Department of Community Service, or DOCS, will offer gynecological screenings and other women's health services once every other week at the shelter.




Gabriel Contreras, M.D., M.P.H.

New Study Shows Cholesterol Counts in Kidney Disease

To understand the health effects of high cholesterol levels, doctors first need to assess malnutrition and inflammation status in their chronic kidney disease  patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

Patients with chronic kidney disease often develop and die from cardiovascular disease. While it's well known that high cholesterol puts people at risk for cardiovascular disease in the general population, the relationship is not as clear in chronic kidney disease patients. In fact, research has shown that dialysis patients with higher cholesterol levels die at a lower rate than those with lower cholesterol levels. It's not that high cholesterol is beneficial; rather, the higher levels may indicate a lesser degree of malnutrition and inflammation, two serious and interrelated complications of kidney disease.

To see whether malnutrition or inflammation might modify the relationship of cholesterol and cardiovascular disease, Gabriel Contreras, M.D., M.P.H., professor of medicine at the Miller School and Lawrence Appel, M.D., from the Welch Center for Prevention, Epidemiology and Prevention, Johns Hopkins University, and colleagues studied 990 African-Americans with hypertension and chronic kidney disease who were not yet on dialysis, 31 percent of whom had malnutrition and/or inflammation. 




Margaret Pericak-Vance, Ph.D.
New Gene Associated with Increased Risk of Alzheimer’s Disease

Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease (AD), the most common type of the disease. Abbreviated MTHFD1L, a gene on chromosome six, was identified in a genome-wide association study by a team of researchers led by Margaret Pericak-Vance, Ph.D., director of the John P. Hussman Institute for Human Genomics at the Miller School. Details appeared September 23 in the open-access journal PLoS Genetics.

The World Health Organization estimates that there are currently 18 million people worldwide with Alzheimer's disease, and this figure is projected to nearly double to 34 million by 2025. By looking at gene variation throughout the human genomes of 2,269 subjects with late-onset AD and 3,107 without the disease, researchers were able to pinpoint small differences in the genetic sequences of people with and without AD.

The study found that individuals with a particular variation in the gene MTHFD1L may be almost twice as likely to develop AD as those people without the variation.




Dean Pascal J. Goldschmidt, M.D., assists as Evril Antoine, R.N., gives Marc Lippman, M.D., his flu shot.
Flu Vaccine Campaign Now Underway at the Miller School

Yes, the needle prick into the deltoid smarts for a second. And no, you won't get a lollipop. (Candy was axed from the budget.) But, as the Miller School's executive leadership learned last week, getting a flu shot is relatively painless and quick, cheerfully and efficiently administered for free at various locales around campus by nurses like Evril Antoine, R.N.

As Dean Pascal J. Goldschmidt, M.D., told Antoine after shedding his lab coat, rolling up his sleeve and baring his arm, "I don't even feel it. You're really, really good."

With the largest order ever of the influenza vaccine in hand, the 2010-11 influenza vaccination campaign officially started September 16, and Dean Goldschmidt and Rafael Campo, M.D., professor of clinical medicine and medical director of employee health for the University of Miami Health System, are counting on even greater participation than last year, when nearly 7,000 doses of the seasonal and H1N1 vaccine were administered at employee health offices.




Ransom Students Learn About Concussions and ImPACT Testing

Behind Miami Project President Marc Buoniconti, center, are from left, Claude Grubair, athletic director; Adam Goldstein, parent; Ellen Moceri, head of Ransom; David Goldstein, student; Gillian Hotz, Ph.D., and Cheryl Goldstein, parent.

The Miller School and the KiDZ Neuroscience Center at The Miami Project to Cure Paralysis held a special assembly at Ransom Everglades School in Coconut Grove this month to educate students about spinal cord injury and concussion in sports.

At the September 13 assembly, Marc Buoniconti, president of The Miami Project to Cure Paralysis, discussed the college football injury that left him paralyzed 25 years ago and the advances in spinal cord injury research, including the start of human trials, that hold promise of a cure.

And Gillian Hotz, Ph.D., director of the Concussion Program at UHealth Sports Medicine, reviewed the signs and symptoms of concussion and described how Ransom students will be tested with ImPACT this fall.




Grand Rounds
Thursday, September 30, 2010 7 a.m. Orthopaedic Grand Rounds: “Cartilage Injuries in the Talus”
Thursday, September 30, 2010 8 a.m. Otolaryngology Grand Rounds: “An Electrophysiological Intra-Operative Monitoring of Hearing During Ossiculoplasty"
Thursday, September 30, 2010 8 a.m. Neurological Surgery Grand Rounds: “Advances and Controversies in the Management of Pituitary Tumors"
Friday, October 1, 2010 1 p.m. Neurology Grand Rounds:  “Assessment of Rapidly Progressive Dementia and Early Diagnosis of Prion Disease"
Tuesday, October 5, 2010 12 p.m. Pathology Grand Rounds: “HPV Carcinogenesis in Head and Neck Tumors”
Wednesday, October 6, 2010 8 a.m. Family Medicine and Community Health Grand Rounds: “Global Health—The Haiti Experience”
Wednesday, October 6, 2010 12 p.m. Medicine Grand Rounds: “How Statisticians Think and Why it Annoys Doctors”
Thursday, October 7, 2010 7 a.m. Orthopaedic Grand Rounds: “Reverse Shoulder Replacement for Fractures and Their Sequelae”
Thursday, October 7, 2010 12 p.m. Department of Medicine Chair Dr. Marc Lippman Presents Pathology Grand Rounds
Thursday, October 7, 2010 12 p.m. Hospital Medicine Grand Rounds: “Providing Quality End-of-Life Care”
Thursday, October 7, 2010 1 p.m. Endocrinology, Diabetes and Metabolism Grand Rounds: “Molecular Regulation of RAGE: Implications for Diabetes and Beyond"
Friday, October 8, 2010 1 p.m. Neurology Grand Rounds: “Dense Array EEG”
Friday, October 8, 2010 2 p.m. Neurology Clinicopathological Conference: “A 61-Year-Old Male with Acute Onset Facial Diplegia, Diplopia and Dysphagia"
Tuesday, October 12, 2010 12 p.m. Cardiovascular Grand Rounds: “Contemporary Management of Paravalvular Leaks”
Wednesday, October 13, 2010 8 a.m. Family Medicine and Community Health Grand Rounds: “The Handoff of Hospitalized Patients”
Thursday, October 14, 2010 7 a.m. Orthopaedic Grand Rounds: “Doing Right and Avoiding Wrong in Orthopaedics Today”
Thursday, October 14, 2010 7:30 a.m. Surgical Grand Rounds: “Preparing for a Terrorist Threat: Defining the Role of the Surgeon”
Thursday, October 14, 2010 12 p.m. Hospital Medicine Grand Rounds: “Update in Obstructive Sleep Apnea”
Friday, October 15, 2010 1 p.m. Neurology Grand Rounds: “Creativity and the Brain”
Tuesday, October 19, 2010 12 p.m. Cardiovascular Grand Rounds: “Diagnosis and Therapy for Vulnerable Plaque”
Wednesday, October 20, 2010 12 p.m. Pathology Grand Rounds: “Thyroid FNA Cytology: Bethesda and Beyond”
Wednesday, October 20, 2010 12 p.m. Epidemiology and Public Health Grand Rounds: “A Randomized Controlled Trial of Structural Ecosystems Therapy for HIV+ Women in Drug Recovery and Their Families"
Wednesday, October 20, 2010 12 p.m. Psychiatry Grand Rounds: “Developmental Factors Underlying the Risk to Develop Anxiety and Depression"
Wednesday, October 20, 2010 12 p.m. Medicine Grand Rounds: “Management of HIV—Beyond HAART”
Wednesday, October 20, 2010 4 p.m. Special Miami Transplant Institute Grand Rounds Presentation and Celebration of 40 Years of Excellence
Thursday, October 21, 2010 7 a.m. Orthopaedic Grand Rounds: “The Biomechanical Rationale for Interosseous Ligament Reconstruction in Essex-Lopresti Injuries"
Thursday, October 21, 2010 7 a.m. Neurological Surgery Grand Rounds: “Surgical Management of Spine Tumors”
Thursday, October 21, 2010 8 a.m. Neurological Surgery Grand Rounds: “Neuropathology”
Thursday, October 21, 2010 8 a.m. Otolaryngology Grand Rounds: “Assessing the Levels of Obstruction in Sleep Apnea”
Thursday, October 21, 2010 12 p.m. Division of Hospital Medicine Grand Rounds: “A Man with Abdominal Pain and Jaundice”
Thursday, October 21, 2010 1:30 p.m. Endocrinology Grand Rounds: “Growth Hormone in Aging”
Tuesday, October 26, 2010 12 p.m. Cardiovascular Grand Rounds: “Carotid Stenting vs. Endarterectomy”
Wednesday, October 27, 2010 7:30 a.m. Plastic Surgery Grand Rounds: “Avoidance and Management of Complications in Lower Eyelid Surgery”
Wednesday, October 27, 2010 8 a.m. Family Medicine and Community Health Grand Rounds: “Promoting Smoking Cessation: Role of the Physician"
Wednesday, October 27, 2010 12 p.m. Department of Medicine Grand Rounds: “Clinical Empathy”
Thursday, October 28, 2010 7 a.m. Neurological Surgery Grand Rounds: “Biomarkers for CNS Injuries: From Benchside to Bedside”
Thursday, October 28, 2010 8 a.m. Otolaryngology Grand Rounds: “Nasal Osteotomy Techniques and Treatment of the Crooked Nose”
Thursday, October 28, 2010 8 a.m. Neurological Surgery/Neurology Grand Rounds: “Collateral Perfusion in Acute Ischemic Stroke”
Friday, October 29, 2010 1 p.m. Neurology Grand Rounds: “What Have We Learned From ADNI?”
Thursday, November 4, 2010 6:45 a.m. Anesthesiology Grand Rounds: “Postoperative Nausea and Vomiting: Can We Ever Get Rid of It?”
Events
Wednesday, September 29, 2010 9 a.m. The Miami Project Wednesday Morning Seminar: “Do Additional Inputs Change Maximal Voluntary Motor Unit Firing Rates After Spinal Cord Injury?"
Wednesday, September 29, 2010 12 p.m. Healthy Steps Presentation: “Clingy Children Who Won’t Let Go: Strategies to Help Your Child Overcome Separation Anxiety"
Thursday, September 30, 2010 12 p.m. Pediatric Clinical Research Forum: “The Incompatibility of Clinical Research and the Common Malady of P Value Neurosis"
Monday, October 4, 2010 12 p.m. Sylvester Comprehensive Cancer Center Seminar: “Target Identification and Inhibition in the Chronic Myeloproliferative Neoplasms"
Thursday, October 7, 2010 12 p.m. Research Roundtable: “Reporting System Overview”
Friday, October 8, 2010 12 p.m. Biochemistry and Molecular Biology Seminar: “Androgen Receptor Coregulators as Biomarkers and Therapeutic Targets in Prostate Cancer"
Friday, October 8, 2010 12 p.m. Ethics Seminar: “Getting to the Good Society—U.S. Research Priorities 2010-2020”
Friday, October 8, 2010 12 p.m. Friday Noon Interdisciplinary Lecture Series
Friday, October 8, 2010 1 p.m. Sylvester Distinguished Lecture: “The Role of Ubiquitination in Signaling Pathways in Inflammation and Cancer"
Tuesday, October 12, 2010 12 p.m. Cell Biology and Anatomy Seminar: “Basic Concepts in Cancer Histopathology”
Wednesday, October 13, 2010 9 a.m. Miami Project Wednesday Morning Seminar: “Recombinant Inhibitory Neuronal Progenitors in Models of Chronic Pain"
Wednesday, October 13, 2010 12 p.m. Pediatric Clinical Research Forum: “Early Detection of Kidney Disease in Preterm Infants”
Thursday, October 14, 2010 12 p.m. Molecular and Cellular Pharmacology Seminar: “Understanding the Molecular Basis of Angiogenesis for Therapy Design"
Thursday, October 14, 2010 12 p.m. Pathology Journal Club Meeting
Thursday, October 14, 2010 7 p.m. The Buoniconti Fund and the Miami Heat’s Chris Bosh Team Up with Neiman Marcus Coral Gables
Friday, October 15, 2010 12 p.m. Friday Noon Interdisciplinary Lecture Series: “Fragile X: A Family of Genetic Disorders”
Friday, October 15, 2010 1 p.m. Neuroscience Center Seminar: “Out on a Limb: Roles for EphA4 and SMN”
Monday, October 18, 2010 12 p.m. Microbiology and Immunology Seminar: “NF-kB Activation and Function: An Alternative View and New Insights Into NF-kB Function in the Nervous System"
Tuesday, October 19, 2010 12 p.m. Developmental Center for AIDS Research Seminar: “Mucosal Immune Responses in HIV Controllers: Location, Location, Location"
Tuesday, October 19, 2010 4 p.m. Genetics/Genomics Seminar: “Emerging Therapeutic Approaches to Mitochondrial Diseases”
Wednesday, October 20, 2010 7:30 a.m. Endocrinology Core Lecture: “Etiopathogenesis and Prevention of Type 2 Diabetes”
Wednesday, October 20, 2010 9 a.m. New Oral and Maxillofacial Surgery Office Opens at University of Miami Hospital
Wednesday, October 20, 2010 12 p.m. Pediatric Clinical Research Forum: “mAKAP and Cardiac Hypertrophy”
Thursday, October 21, 2010 1 p.m. Biochemistry and Molecular Biology Seminar: “Nutritional Modulation of Environmental Toxicity: Implications in Atherosclerosis"
Thursday, October 21, 2010 1 p.m. Endocrinology Fellows Clinical Case Conference: “The Diagnostic Challenges of Growth Hormone Deficiency"
Thursday, October 21, 2010 2:45 p.m. Endocrinology Research Conference: “Role of Type 3 Deiodinase (D3) in Pancreatic Islet Function”
Friday, October 22, 2010 12 p.m. Biochemistry and Molecular Biology Seminar: “Astroglial-NF-kB is an Important Regulator of Learning and Memory and Neurogenesis in Female Mice"
Saturday, October 23, 2010 3 p.m. Cancelled: Bike to the BankAtlantic Center
Sunday, October 24, 2010 10 a.m. 2010 Miami-Dade County “Out of the Darkness” 5K Walk for Suicide Prevention
Monday, October 25, 2010 10 a.m. Sylvester Comprehensive Cancer Center Seminar: “Bayesian Statistical Methods for the Design of Early Phase Cancer Trials and Analysis of Longitudinal Cancer Data"
Tuesday, October 26, 2010 12 p.m. Cell Biology and Anatomy Seminar: “ROS-Sensitive Association of Respiratory Complexes into Supercomplexes"
Tuesday, October 26, 2010 3:30 p.m. Anesthesiology Seminar: “Bedside to Bench: What Can We Learn About Migraine by Studying the Mechanisms of Action of Triptans?"
Wednesday, October 27, 2010 9 a.m. Miami Project Wednesday Morning Seminar: “Axon Formation”
Wednesday, October 27, 2010 12 p.m. Sylvester Distinguished Lecture: “Intracellular Antibodies as Inhibitors of Hepatitis C Virus Replication"
Wednesday, October 27, 2010 12 p.m. Healthy Steps Seminar: “School Readiness: Is Your Child Ready? Are You Ready?”
Wednesday, October 27, 2010 12 p.m. Pediatric Clinical Research Forum: “History of Whole Body Periodic Acceleration (WBPA) 1996-”
Wednesday, October 27, 2010 4 p.m. McKnight Research Seminar: “Deiminated REF Mediated mRNA Transport to Mitochondrial Surface in a Transgenic Mice Model of Multiple Sclerosis"
Thursday, October 28, 2010 8:30 a.m. Sylvester and University of Miami/Jackson Town Hall Meeting
Thursday, October 28, 2010 12 p.m. Brown Bag Lunch-and-Learn Seminar: “IRB 101”
Thursday, October 28, 2010 1:30 p.m. Molecular and Cellular Pharmacology and Division of Endocrinology to Host Seminar
Friday, October 29, 2010 9 a.m. The Miami Project to Cure Paralysis Seminar: “Brain-Machine Interfaces in Neuromedicine: Harnessing the Coding of Behavior from Neural Ensembles"
Friday, October 29, 2010 12 p.m. Biochemistry and Molecular Biology Seminar: “Structure and Function of Insect Odorant Receptors”
Friday, October 29, 2010 2 p.m. Neurology Clinicopathological Conference: “57-Year-Old Female with Progressive Lower Extremity Numbness"
Saturday, October 30, 2010 9 a.m. DOCS Little Haiti Health Fair
Saturday, October 30, 2010 10 a.m. 2010 Start! Heart Walk
Tuesday, November 2, 2010 12 p.m. Cell Biology and Anatomy Seminar: “Tissue Specific Control of Thyroid Hormone Action”
Wednesday, November 3, 2010 12 p.m. Gail F. Beach Memorial Visiting Lectureship: “Microglial Activation, Neuronal Death and Glial Regeneration After SCI"
Wednesday, November 3, 2010 12 p.m. Monthly Networking Meeting for Clinical Research Professionals
Friday, November 5, 2010 1 p.m. Neuroscience Center Seminar: “The Brain’s Logic for Storing Memories”
Monday, November 8, 2010 11 a.m. United Way Raffle Features Travel Prizes
Monday, November 8, 2010 4 p.m. Genetics/Genomics Seminar: “Genome Structure and Expression”
Friday, November 12, 2010 1 p.m. Sylvester Distinguished Lecture: “Cellular Phenotyping of Breast Tumors”
Saturday, November 13, 2010 8:30 a.m. College of Engineering and SEEDS Writing Workshop
Thursday, November 18, 2010 12 p.m. Office of Finance and Treasury 2010 United Way Silent Auction

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The University of Miami is an Equal Opportunity/Affirmative Action University.

Senior Vice President for Medical Affairs and Dean
University of Miami Miller School of Medicine
CEO, University of Miami Health System
Pascal J. Goldschmidt, M.D.

Executive Editor
Associate Vice President for Communications
Christine Morris

Editor
Jenny Prather

Contributors
Maya Bell
Dwayne Campbell
Jeanne Antol Krull
Lisa Worley


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