The University will conduct its second full-scale test of its Emergency Notification Network (ENN) this Thursday beginning at 12:15 p.m.

Last year the University invested in additional resources to enhance timely communications to students, faculty and staff in the event of a crisis. The ENN is a comprehensive communications system that can rapidly disseminate an urgent message through multiple mediums including voice messages to cell, home and office phones; text messages to cell phones; e-mail messages; emergency notification sirens; and public address and loudspeaker messages in some residence halls and other buildings. Please note that outdoor emergency notification sirens on the Coral Gables campus will be a part of the event.

ENN messages will be sent to every member of the University community who has registered their personal contact information on MyUM. Please take a moment to confirm that your information on MyUM is registered and up-to-date. Individuals who have not registered or have out-dated information on MyUM will not receive ENN phone or e-mail messages.

All messages sent as part of this exercise will clearly indicate that it is a test. To simulate an emergency situation, primary and follow up test messages will be sent; not all individuals will receive both messages.

A full explanation of the ENN system, frequently asked questions and step-by-step registration directions are available on the emergency preparedness Web site at www.miami.edu/prepare. Please assist the University in this important initiative by sharing news about the network and test with your colleagues.

“The Miller School’s commitment to providing assistance and medical care to Haiti has never been stronger than it is during this terrible time of need,” said Dean Goldschmidt.  For many years UM’s Project Medishare, co-founded by Barth Green, M.D., professor and chairman of neurological surgery, and Arthur Fournier, M.D., professor of family medicine and associate dean for community health, has been providing medical care to one of Haiti’s poorest regions, the Central Plateau. 
 
For more on this story, click here.

The molecule, acetyltransferase p300, is essential for cardiac development. Using mouse models, the research team found that excess amounts of p300 in the heart lead to a corresponding degree of hypertrophy.  Reducing p300 resulted in less hypertrophy in response to stress such as high blood pressure, and too much p300 led to spontaneous hypertrophy and eventually to heart failure and death.

“The data shows that p300 is responsible for driving hypertrophy after pressure overload and for driving the subsequent heart failure,” said Bishopric, professor of medicine, pediatrics and pharmacology at the Miller School. The findings, published in August in the prestigious journal Circulation, suggest that regulating p300 could protect against stress-induced hypertrophy and forestall the development of heart failure. For more on this story, click here.

The James W. McLamore Outstanding Service Award recognizes service above and beyond the call of duty by a member of the University community. Nomination materials are due by Friday, October 3. For more information, please visit https://www.miami.edu/faculty-senate/Awards/chargeMcLamore08.doc.

The Outstanding Teaching Award recognizes outstanding teaching by a faculty member with a substantial record of teaching at the University. Nomination materials are due by Friday, October 10. For more information, please visit https://www.miami.edu/faculty-senate/Awards/chargeOTA08.doc. 

Distinguished Faculty Scholar Award recognizes either a single outstanding scholarly achievement or a lifetime of distinguished accomplishment in any area of research or creative activity. Nomination materials are due by Friday, November 7. For more information, visit https://www.miami.edu/faculty-senate/Awards/chargeDFSA08.doc.

Should you have any questions or need assistance, please do not hesitate to contact the office at 305-284-3721 or facsen@miami.edu.

Oct. 3: “Food, Nutrition and Diet Therapy: Clinical Applications” - Bernd Wollschlaeger, M.D.

Oct. 10: “The Functional Medicine Matrix” - Leonard Smith, M.D.                    
 
Oct. 17: “Foundations for Successful Weight Management” - David Hogsed, AP, D.O.M.     
 
Oct. 24: “An Integrative Medical Approach to the Metabolic Syndrome and Alzheimer’s Disease” - Richard Delany, M.D. 
 
Nov. 7: “Malnourished Minds: Integrative and Orthomolecular Treatments for Depression” - James Greenblatt, M.D.                 
 
Nov. 14: “Chronic Stress Response: Using Natural Treatment Alternatives and Natural Therapies for Normalizing Hypothalmus/Pituitary/Thyroid Axis” - Gail Marshall, A.R.N.P., M.S.N.       
 
Dec. 5: “Herbal Medicine and Cancer” – Fu Di, M.D., AP                           
 
Dec. 12: “Metabolic Biotransformation and Bioactivation: An Introduction & Overview of Detoxification” - Bruce Bond, DC, D.A.C.B.N.          

For more information or to register, please e-mail Jason Torres at jtorres2@med.miami.edu.

Raffle tickets are $5 each. To purchase your raffle ticket or join the Tropical Rhythm's team, please contact Julissa Gutierrez or Laz Gordon at 305-243-9200. You can also visit the Web site at http://www.med.miami.edu/imi/x88.xml to learn more. The drawing will take place at noon on Wednesday, October 8, at the International Medicine Institute located in Dominion Tower, conference room 206A.

For more information, please contact Javier Salazar at 305-585-6042 or jsalazar@med.miami.edu.

For more information, please contact Jeanne Tamargo at 305-243-8125 or jtamargo@med.miami.edu.

For more information, please contact Karen Harvey at 305-243-1960 or Kharvey@med.miami.edu.

Everyone is encouraged and welcome to attend this presentation. The event will take place on Wednesday, September 17, at noon in the Broad-Bussel auditorium located on the first floor of the Clinical Research Building. Lunch will be served at 11:30 a.m. No RSVP is required.

For more information, please contact Marsha Williams at 305-585-6973 or mwilliams@med.miami.edu.

For more information, please contact Elisa Arguelles at 305-585-1280 or earguelles@med.miami.edu.

For more information on the seminar, please contact Michelle Perez at 305-243-6655 or miperez@miami.edu.

The lecture will take place this Thursday, at noon in the Rosenstiel Medical Science Building, third-floor auditorium. A light lunch will be provided on a first-come, first-served basis. The lecture is eligible for one continuing medical education credit or one nursing contact hour. For more information or to expedite processing of your credit, please contact Vanessa Moreno at 305-243-2576.

A list of upcoming Institute for Women’s Health Grand Rounds is available online at http://womenshealth.med.miami.edu/x21.xml.

For a $10 donation, riders can stop at five designated locations along the way to draw what could be a winning poker hand. Poker hand donations benefit the Diabetes Research Institute and the Key West Sunrise Rotary Club.

Players can sign up at Peterson’s Harley Davidson of Miami located at 19400 NW 2nd Avenue, or Peterson’s Harley Davidson South at 19825 South Dixie Highway. Registration is also available online at www.petersonskeywestpokerrun.com.

Anyone who would like to meet with the speaker should contact Sylka Perez at 305-243-6265 or sperez6@med.miami.edu.

For more information, contact Coretha Davis at c.davis2@miami.edu.

Please register online at http://ulearn.miami.edu/. The seminar will take place on Tuesday, September 23, from noon to 1 p.m. at Dominion Parking Garage, suite 155. For questions, please visit www.miami.edu/benefits/ask and complete the online form.

For more information, please contact Elisa Arguelles at 305-585-1280 or earguelles@med.miami.edu.

Lunch will be provided on a first-come, first-served basis. No RSVP is required. For more information, please contact Amanda Grabloski at 305-243-4889 or agrabloski@med.miami.edu.

For more information, please contact Karen Harvey at 305-243-1960 or Kharvey@med.miami.edu.

Dr. Ritvo and long-time friend, Debra Luftman, M.D., a board-certified dermatologist, wrote the book together to create a guide to becoming beautiful, inside and out. Ritvo will sign books and discuss the main components of the book—how outer and inner beauty, health, and environment affect people’s view of themselves.

If you would like more information on the book, please visit www.thebeautyprescription.com.

The presenters will be Michael Alessandri, Ph.D., Jeffrey Brosco, M.D., Ph.D., Monica Dowling, Ph.D., and Ven Sequenzia, president of the Autism Society of Florida. Continuing education units and master plan points will be offered. The registration cost is $50 for professionals and $25 for students. Breakfast, lunch and snacks will be served. For additional information, please contact Wanda Denise Castro at wcastro@med.miam.edu or 305-243-4466.

For more information, please contact Alicia Cabrera at 305-585-6103.

For more information, please contact the Diabetes Research Institute Foundation at 954-964-4040 or 800-321-3437, or visit www.diabetesresearch.org.

The Departments of Neurology and Radiology are conducting research studies examining age-related changes in cognitive and motor function, along with new brain imaging techniques. Participants should be healthy adults over age 40 with no history of major neurologic or psychiatric disease. Eligible participants will be asked to participate in activities to assess verbal/non-verbal skills and motor function. Some studies include an MRI at no cost. If you are interested in participating, please call 305-243-7529 to speak to the study coordinator.

The Departments of Neurology and Radiology are conducting research studies to examine changes in cognitive and motor function, along with new brain imaging techniques. Participants must be between the ages of 40 to 79 with Parkinson’s disease. Eligible participants will perform activities to assess verbal/non-verbal skills and motor function. MRI's, if conducted, will be done at no cost. If you are interested in participating, please call 305-243-7529 to speak to the study coordinator.

Keloid scars
Heather Woolery-Lloyd, M.D., of the Cosmetic Medicine and Research Institute, is looking for men and women between the ages of 18 and 65 who have keloid scars to participate in a clinical research study. The study will determine whether use of an investigational treatment known as Apligraf®, a product with an epidermis and dermis layer like skin, will reduce recurrence of keloids. The study duration is 52 weeks and requires up to 13 visits. If interested, please contact a member of the research staff at 305-531-5788 or visit www.derm.net.

Physician-Patient Relationship Study
The Center on Aging is conducting a study on the impact of patient-acquired Internet health information on physician-patient relationships. The study will explore how this information affects office visits and the overall positive and negative outcomes that result from patients using the Internet for health information. If you are a physician who sees patients and are interested in participating in a brief interview study, please contact Jessica Hirth at 305-355-9020 or jhirth@med.miami.edu.

El Centro, Center of Excellence for Hispanic Health Disparities Research, is recruiting participants for the following studies:

 •Project VIDA (Violence, Intimate Relationships & Drugs Among Latinos)
Elias Vasquez, Ph.D., and colleagues are recruiting Hispanic men ages 18 to 55 for a pilot study exploring substance abuse, violence, risky sexual behaviors and associated conditions among this population. The results from this study will be used for interventions to reduce these conditions among Hispanic men in South Florida. 

 •Preventing HIV and Sexually Transmitted Infections in Hispanic Women
Nilda Peragallo, Dr.P.H., is recruiting Hispanic women ages 18 to 50 for a randomized trial of a group intervention to reduce sexual risk behaviors and intimate partner violence. To be eligible, women must have been sexually active during the 3 months prior to enrollment. 

 •Treating Behavior Problems and Promoting Healthy Development in Hispanic Adolescents
Daniel Santisteban, Ph.D., is recruiting Hispanic adolescents ages 11 to 14 and their families for a randomized trial comparing family-based and individually-based treatments to reduce current behavior problems and prevent future substance use and risky sexual behaviors in adolescents. To be eligible, the adolescent must be Hispanic and have difficulties in two of the following four areas: conduct, depression, attention deficit, or family conflict. 

For more information on studies conducted by El Centro, contact Tania Lopez at 1-888-262-9481 or tlopez1@miami.edu.

Mild to Moderate Rosacea
Leslie Baumann, M.D., professor and director of the Cosmetic Medicine and Research Institute, is looking for men and women over 18 who have mild to moderate rosacea. If you are interested in participating, contact a member of the research staff at 305-531-5788 or cosmeticresearch@med.miami.edu. You may also visit the Cosmetic Center online at www.derm.net for more information.

Jennifer Marks, M.D., is currently recruiting patients ages 18 or older, who are obese with impaired glucose tolerance and have hypertension, for participation in a study to evaluate the safety and effectiveness of an angiotensin receptor blocker for protection against endothelial dysfunction. Patients must be non-smokers who are otherwise in good health. Those who are interested should contact Jorge Mejia-Galvis, Ph.D., at 305-243-6573.

Sleep Maintenance Insomnia
Robert Schwartz, M.D., is recruiting subjects who are 18 years or older and have trouble sleeping through the night. Subjects must have insomnia for at least one month and have clinically significant distress or impairment in social, occupational or other important areas of functioning. Those interested should contact Linda Cenci or Luis Roque at 305-243-1247, lcenci@med.miami.edu or lroque@med.miami.edu. 

The Division of Geriatrics is recruiting men and women age 65 and older to take part in a study of vitamin D in the prevention of frailty. Participants are asked to come for six visits over six months for blood and urine tests. If you or someone you know are interested, please call Silvina Levis, M.D., at 305-243-4330.

Study to Compare the Methods of Collecting Urine Samples for the Diagnosis of Urinary Tract Infections
The Institute for Women's Health is conducting a research study for the treatment of urinary tract infection (UTI), a very common problem in young, healthy women that afflicts approximately one-half of women by their late 50's. Urine specimens collected for the diagnosis of urinary tract infection are often contaminated with organisms and the major purpose of this study is to compare the methods (voided versus catheter) of collecting the urine samples for the diagnosis of UTI. If you are a female between the ages of 18 to 49, currently experiencing painful urination for less than seven days and frequent trips to the restroom, you may be able to take part in this study. To find out more, call Wisvline Labrousse, Ph.D., A.R.N.P., at 305-243-2576.

Urinary Tract Infection Antibiotic Treatment  Study
The Institute for Women's Health is conducting a research study for the treatment of urinary tract infection (UTI), a very common problem in young, healthy women that afflicts approximately one-half of women by their late 50's. The purpose of this study is to assess the efficacy and tolerance of a three-day regimen of standard antibiotics currently used for the treatment of UTI. If you are female between the ages of 18 to 45, currently experiencing painful urination and frequent trips to the restroom, you may be able to take part in this study. To find out more, call Wisvline Labrousse, Ph.D., A.R.N.P., at 305-243-2576.

Pregnant Women Needed for Urinary Tract Infection Study
The Institute for Women's Health and the Department of Obstetrics and Gynecology at the Miller School are seeking the participation of pregnant women at least 18 years of age and over to help in a clinical research study on urinary tract infection and its treatment during pregnancy. The study involves screening pregnant women in the early stages of pregnancy and following them at their regular scheduled visits until delivery. We will also determine the optimal duration of treatment of asymptomatic urinary tract infection in pregnancy. Research study visits will include completion of a questionnaire, health history, and collection of urine samples at scheduled visits until delivery. All study-related visits, lab work and medications will be free; participants will be compensated for the completed study visits. For more information, please call Wisvline Labrousse, Ph.D., A.R.N.P., at 305-243-2576

Melasma Study
Heather Woolery-Lloyd, M.D., of the Cosmetic Medicine and Research Institute, is looking for female subjects between the ages of 18 and 50 who have melasma, brown spots on the face, to participate in a research study to determine whether an oral sunscreen is safe and effective in the treatment of melasma. If interested, please contact a member of the research staff at 305-531-5788 or cosmeticresearch@med.maimi.edu.

Leslie Baumann, M.D., professor and director of the Cosmetic Medicine and Research Institute, is recruiting for studies on photoaging, fine lines, wrinkles, crow's feet, sun damage, brown spots, uneven pigmentation, acne, keloids, scars and loose skin on the abdomen or upper arms. If you are interested in any of these studies, please call our research team at 305-531-5788 or visit the Web site at www.derm.net. Studies will take place at the Cosmetic Medicine and Research Institute located in the Miami Heart Institute, 4701 N. Meridian Avenue, Nichol Building, Suite 7450, Miami Beach.

The Center for Liver Diseases is looking for volunteers with liver (hepatic) disease who are 18 years or older to test the safety of a new drug. For more information, please call Carlos Quintero at 305-243-2854.

The Center for Liver Diseases is also conducting a research study on patients with hepatitis C viral infection (HCV). Patients must be at least 18 years of age with resistance to prior treatment. Qualified patients will receive treatment without cost. If you or someone you know is interested in participating in this study, please call Carlos Quintero at 305-243-2854.

The Islet Cell Transplant Center at the Diabetes Research Institute is recruiting subjects with type 1 diabetes mellitus to participate in research studies that involve transplantation of islets, the insulin producing cells of the pancreas. For more information and eligibility criteria, call the department at 305-243-5321 or view the clinical trials section of the Web site www.diabetesresearch.org.

The Department of Psychology and the Sylvester Comprehensive Cancer Center Division of Biobehavioral Oncology and Cancer Epidemiology are conducting an NCI-funded quality of life research study with patients recently diagnosed with prostate cancer. Participants are eligible if they have been diagnosed with prostate cancer within 3 months and have not begun treatment. All participants will be followed for two years and will undergo psychosocial and medical assessments. Participants will be reimbursed up to $250 for their time and effort. If you or someone you know may be interested in more information about this study, please contact Natalie Escobio at 305-243-3329 or nescobio@med.miami.edu.  

Robert M. Jackson, M.D., from the Division of Pulmonary and Critical Care Medicine, is seeking idiopathic pulmonary fibrosis (IPF) patients for an ongoing phase II clinical trial of vasodilator therapy (sildenafil). The objectives will be to assess possible therapeutic benefits of a vasodilator, sildenafil, on exercise tolerance and dyspnea in IPF patients and to observe changes in post-exercise markers of oxidant stress. The investigators seek patients with mild to moderate IPF and who have been diagnosed clinically. The study is open to at least ten additional patients. For more information, please contact Robert M. Jackson, M.D. or IPF program coordinator Carol Ramos at 305-575-3548 or by e-mail at rjackson2@med.miami.edu. This trial is funded by the Veterans Administration Research Service and is open to non-veterans of both genders. More information can be found at http://clinicaltrials.gov/ct/show/NCT00359736?order=2.

The Department of Psychology and the Division of Biobehavioral Oncology, Prevention, Epidemiology and Control at the Sylvester Comprehensive Cancer Center are conducting an NIH-funded intervention study to examine the effects of stress management on health and quality of life in women recently diagnosed with breast cancer (stages 0-III). Participants must have recently had surgery for breast cancer, have not yet begun chemotherapy or radiation treatment, and have fluency in English. Eligible women will participate in weekly group sessions over a period of five weeks and be compensated for completing three assessments (questionnaire packet, saliva collection, and blood draw). If you are interested in participating or would like further information about this study, please contact the study coordinator, Janny Rodriguez, at 305-284-2220 or jannyr@miami.edu.

Jay Skyler, M.D., and Jennifer Marks, M.D., from the Diabetes Research Institute, are currently recruiting patients 18 years of age and older with type 1 diabetes mellitus for participation in research studies to evaluate the safety and effectiveness of inhaled insulin. Patients must be taking multiple insulin injections daily, be non-smokers and in good health. Those who are interested should contact Rogelio Suarez at 305-243-6573 or rsuarez2@med.miami.edu.

Jennifer Marks, M.D., is currently recruiting patients ages 18 through 40 with type 1 diabetes mellitus with a recent diagnosis for participation in a research study to test the safety and effectiveness of an investigational medication. Patients must be taking multiple insulin injections daily and in good health. Those who are interested should contact Rogelio Suarez at 305-243-6573 or rsuarez2@med.miami.edu.

 Robert Kirsner, M.D., Ph.D., vice chairman of the Department of Dermatology and Cutaneous Surgery, is looking for people with foot ulcers as a complication of diabetes or venous insufficiency. Please contact Carol Kittles at 305-243-8485 for additional information on these studies.

The Department of Psychiatry and Behavioral Sciences is conducting a federally funded HIV behavioral intervention research study for women and their partners, the New Opportunities for Women 2 (NOW 2) Project. The project will address topics related to safer sex, sexual risk reduction, STDs and communication skills. The NOW 2 Project is currently recruiting English-speaking couples, in which one or both individuals must be HIV positive. Participants must be 18 years or older, willing to be tested for STDs, and answer personal questions in a confidential interview. Women and men who participate may each receive compensation of up to $360 for an entire year of participation (this includes attendance at all interviews, examinations and sessions). If interested, please contact Arnetta Phillips or Jackie Gomez, at 305-243-2103, or (aphillips@yahoo.com / jgomez4@med.miami.edu).

Do you or someone you know experience pain related to spinal cord injury? Eva Widerström-Noga, Ph.D., and her colleagues are conducting research into the nature and treatment of pain associated with spinal cord injury. Studies are enrolling now.  Eligible participants will be 18 to 70 years of age and at least two years post-injury.  If you are interested in enrolling, please call The Miami Project to Cure Paralysis at 305-243-8132 for information.

The Department of Psychology is recruiting participants for the following studies:

• A schizophrenia family study 
Have you or one of your relatives been diagnosed with schizophrenia or schizoaffective disorder? Are you in regular contact with this person? If so, you and your family may be eligible to participate in a free family-focused treatment research study. During the treatment, clinicians will provide factual information about schizophrenia and schizoaffective disorder. In addition, techniques to assist the family in coping with mental illness will be presented. Treatment is available in English and Spanish. If interested, please contact the Schizophrenia Family Project at 305-284-5455.

• A family factors and autism study
The aim of this project is to better understand families’ emotional reactions to autism spectrum disorders. We seek the participation of adults with high-functioning autism or Asperger’s and one of his or her parents. Participation will involve one hour-long telephone call. If you would like to help with this study or if you have any questions, please contact Stephanie Wasserman at 305-284-2307.

Researchers at the MRI Center need healthy subjects for a magnetic resonance imaging study. For more information, please visit http://midas.med.miami.edu/Research/MRStudies.htm.

The Department of Psychology and the Division of Cancer Prevention and Control is conducting a quality of life research intervention with advanced prostate cancer patients. Participants should have Stage III or IV prostate cancer and have recently or currently been treated with hormone therapy. Eligible participants will take part in a ten-week cognitive behavioral stress and affect management program or a health promotions program. Three psychosocial/medical assessments are also required. If you are interested in this study or would like more information, please contact Frank Penedo, Ph.D., at 305-243-3329, or fpenedo@miami.edu.

Daniel Santisteban, Ph.D., at the Center for Family Studies is currently conducting a research program that would provide adolescents and/or their family treatment for free. Participants must be 14 to 17 years old, have a parent or legal guardian willing to participate, meet DSM criteria for both substance abuse disorder and borderline personality disorder, and be willing to participate in four separate, paid evaluations. If interested, please contact Maite Mena, Psy.D., at 305-243-3658, or mmena@med.miami.edu for details. 

The Center for Research and Education on Aging and Technology Enhancement is conducting research with family caregivers of dementia patients who speak English and are 50 years of age or older. If you are not a caregiver but are interested in participating, you may be able to help as well. Participants will receive basic training on how to use the Internet and will be asked to look for information about care-giving and dementia. If you are interested in being a part of this research study, please call 305-355-9200. You will be paid for your time and effort.

The AIDS Clinical Research Unit, directed by Margaret Fischl, M.D., is recruiting participants for the following studies:

• An investigational polyclonal caprine IgG, HRG214, for HIV patients not responding to antiretroviral therapy. HRG214 contains antibodies that targets HIV infected CD4 cells and specific regions on HIV. Laboratory/animal studies suggest these antibodies are capable of killing or disabling HIV and preventing further infection.  Participants must have HIV RNA < 5000 copies/ml and CD4 cells < 200 cells/cmm. The study will evaluate 3 increasing dose of HRG214 in part I and compare HRG214 to optimized antiretroviral therapy in part II. HFG214 is given IV over about 30 minutes three times a week for up to 26 weeks. $100 provided each completed week of HRG214 treatment and $25 each completed week of observation

 • A phase II study of investigation use of recombination human keratinocyte growth factor (rHuKGF, palifermin) for patients with incomplete immune recovery on HAART.  rHuKGF may enhance thymus production of lymphocytes and increase CD4 cell counts. Participants must be 18 years and older, receiving antiretroviral therapy for at least 6 months with HIV RNA <200 and CD4 cell count <200 cells.  The study will evaluate 3 doses (20, 40 60 mcg/kg) of rHuKGF compared to placebo.  rHuKGF given IV bolus daily for 3 days. Follow up study visits at weeks 1, 2, 4, 8, 12 and 24 with thymus CT scans at entry and week 12.

 • A phase II of an investigational glycosylated recombinant human IL-7 (CYT017, a cytokine that aids T-cell development and improves T-cell survival). Participants must be 18 years of age, receiving HAART for at least 12 months and have an HIV-1 RNA level < 1,000 copies/ml and CD4 cell count of 101 - 400 cells/ccm. The study will evaluate three increasing doses (10, 20, 30 Fg/kg) of IL-7 given by SQ injection once a week for 3 weeks. Up to $275 in food certificates provided.

For more information on studies conducted by the AIDS Clinical Research Unit, contact Juan at 305-243-3838 or Leslie at L.Thompson@miami.edu.

Bruce Rubin, M.D., is currently performing a study on trigeminal neuralgia (TN) treatment with subcutaneous injections of BOTOX® to evaluate the effectiveness of treating facial pain associated with TN. Patients must have a diagnosis of TN for more than three months and be at least 18 years of age.
 
Dr. Rubin is also seeking patients for a research study on the treatment of tightness/spasticity in the wrist, fingers, and elbow caused by a stroke while evaluating the effect of BOTOX® on pulmonary functioning. Patients must be 18 years of age, have had a stroke six months ago or longer, have a pulmonary/breathing problem and cannot have used BOTOX® or any other botulinum toxin previously for any condition. Please contact Amy L. Kaye, ARNP, at 305-243-6223 for additional information on either of these studies.